Natural or synthetic gestagen therapy may exacerbate existing low-grade or 'smoldering' uterine inflammation into a fulminating uterine infection in some instances. Detach syringe and administer solution orally at the rate of 1 mL per 110 pounds body weight (0.044 mg/kg) once daily for 15 consecutive days. Treatment of placentitis-affected mares with a double-dose of the oral version of altrenogest "Regumate ® " has been suggested, [22] [23] but while beneficial under the circumstances, the effect of this dosage on "forced" maintenance of an undesirable pregnancy has . Consequently, endogenous progesterone levels may be monitored while a mare is being treated with altrenogest. High plasma progesterone levels in mares suppress oestrus behaviour. Simply apply the Regu-Mate solution at either the base of the mare's tongue or directly on her grain. Dosage and Administration: How does Regu-Mate Solution work? DOSAGE AND ADMINISTRATION. When treatment is discontinued, mares return to estrus within 4 to 5 days. Money back guarantee to improve your mare's health and comfort. Progesterone also has an inhibitory effect. In filly offspring (all ages) of treated mares, clitoral size was increased. Dosage: 1ml per 110 lbs body weight orally for 15 consecutive days. 3mL per 500kg bodyweight by intramuscular injection once every 5-7 days as required to suppress signs of oestrus. 1.8 mg) is less effective at inducing ovulation in low-dose deslorelin treated mares; Low-dose deslorelin therapy is MORE EFFECTIVE IN TRANSITIONAL MARES than mares in deep anestrus after completion of It has however been shown that mares will "foal through Regumate" . Active ingredient: Altrenogest. The recommended dosage of Regu-Mate is 1 ml per 110 lbs body weight given once daily for 15 consecutive days. As low as 1.25 to 2.5 mg has induced a normal estrus in 11 mares with 32 cycles (Barker. The only mare product to reduce mare issues that has High Dose Vitamin E, 8 herbs, 2 added vitamins and minerals. The metabolism of Regumate by the mare's body requires that it be given daily to maintain the optimal level of 4ng/ml in the mare's bloodstream. However, what is the clinical evidence for . Theriogenology 66 (2006) 686. feedback effect on the hypothalamic-pituitary axis. It contains the active synthetic progestin - altrenogest. It is meant to be used for the suppression of estrus in mares. The usual dose is 1 ml per 110 lbs body weight once daily for 15 consecutive days. Regu-Mate® is used to conveniently suppress estrus in mares, control the time that estrus starts, and shorten prolonged estrus. One of the mares in the treatment group died as a result of an intestinal crisis in week 10 and results for . Mare Support REGUMARE helps support the normal hormonal balance of mares when temperament and marish behaviour adversely affects safe handling, willingness to work or focus in the ring or on the track. Regumate® or altrenogest is a synthetic progestin approved for suppression of estrus in mares. Replace cover on bottle dispensing tip to prevent leakage. Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal. How rapidly does Regumate work? Alternatively, a dose of 0.1 to 0.5 mg (0.1 cc) given twice at a 24 hr interval can be used. For the suppression of oestrus in normally cycling mares. It can be given daily to a mare early in her season and usually within 3 days it will stop that oestrus. Efficacy studies were performed on Thoroughbred horses with an average weight of 500kg using a dose of 3 mL per horse every 7 days. Replace cover on bottle dispensing tip to prevent leakage. Regu-Mate Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal. Regumate can continue to be given once daily afterwards to prevent the return to oestrus. Why use Regu-Mate Solution? This facilitates the attainment of regular cyclicity during the transition from winter anestrus to the physiological breeding season. Helps settle squealing and excess flirting. 2. Regu-Mate altrenogest Solution 0.22% is indicated to suppress estrus in mares. I use regumate (porcine) with my mare basically from the first sign of first season - was Feb this year - until Sept/October. The Ergonomic design gives maximum user comfort and stylish looks. Regumate® can be used to accomplish both tasks. I gave her a loading dose of Banamine, deeply bedded her stall, iced her feet and called the vets. Use intermittently when your mare is coming into . Regumate is generally extremely well tolerated by mares, and is highly unlikely to produce any undesirable side effects. Administer solution directly on the base of the mare's tongue or on the mare's usual grain ration. She then proceeded to tell me that on a hunch, she dosed these mares with Regumate to inhibit their cycles.. just in case the heat cycle was the trigger. If a mare's problems are hormonal, it will work, provided the dose is sufficient and it's used absolutely on order. Helpful. Dosage Administer orally with dose syringe or by placing directly on feed. on the secretion of luteinising hormone, via a negative. Suppression of behavioral estrus, synchronization of estrus, maintenance of pregnancy. Clinical uses of Regumate include management of the transition period, suppression of heat in performance mares and maintenance of pregnancy in problem mares. It is supplied as a liquid to be given directly into the mouth or added to a small amount of food. It can be given daily to a mare early in her season and usually within 3 days it will stop that oestrus. Mare Health. Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal in mares with ovarian follicles 20 mm or greater. HI, I'm Dr Steve. It is the only such medication proven to have progesterone-type biologic activity in the horse. Oral progestin solution for suppression of estrus in mares. Regu Mate will facilitate attainment of regular cyclicity during the transition from winter anestrus to the physiological breeding season. n Regu-Mate effectively suppresses estrus in 95 percent of mares after 3 days of treatment. The oral synthetic progestin altrenogest (Regumate. Regumate Equine 2,2 mg/ml 1000 ml. Treated mares received 2 mL Regu-Mate ® (altrenogest) Solution 0.22% /110 lb body weight (2 x dosage recommended for estrus suppression) from day 20 to day 325 of gestation. Dangerous for females to handle, the drug must be administered in precise dosage on a daily basis. Consult with your veterinarian for any potential side effect concerns. Pharmacokinetic data from mares treated with Ovu-Mate, have shown blood levels of altrenogest are maintained for 5 days following administration of the injection. Treated mares received 2 mL Regu-Mate ® (altrenogest) Solution 0.22% /110 lb body weight (2 × dosage recommended for estrus suppression) from day 20 to day 325 of gestation. The mare will experience a predictable occurrence of estrus following drug withdrawal. Regu-Mate can help alleviate moodiness and temperament changes associated with estrus. Product: Regumate® Equine 2.2 mg/ml oral solution for horses. The mare is subsequently administered hCG to induce ovulation; note that administration of a 'high-dose' of deslorelin (i.e. "The reality is that many of these mares that are on it every day for months and months, it's not a cyclical behavioral issue," he said. 3/ All references to regumate refer to 'long periods' as being perhaps a whole summer, for example. Pregnant women or women who suspect they are pregnant should not handle Regu-Mate®. Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal, which permits scheduled breeding of mares during the breeding season. Species: Horses and other equidae. Regu-mate is an artificial type of progesterone. Regu-Mate (altrenogest) Solution 0.22% is indicated to suppress estrus (period of the reproductive cycle when the mare ovulates and, if bred, is likely to conceive) in mares. I wouldn't want to use Regumate without this device-nobody needs extra exposure to these kinds of hormones. A hormone is a hormone is a hormone. If Regu-Mate is added to feed, any medicated feed left over should be destroyed and should not be given to other animals. Questions & Answers Product Description Regu-Mate Solution Indicated to suppress estrus in mares. Are there any side effects? Detach syringe and administer solution orally at the rate of 1 mL per 110 pounds of body weight (0.044 mg/kg) once daily for 15 consecutive days. Therapeutic indication: Pharmaceuticals: Hormones and therapeutically related products: Other sex hormones. Regumate Equine is used to control oestrus ("heat") in mares. Regumate Equine is used to control oestrus ("heat") in mares. Helps reduce sensitivity to being groomed or tacked-up. Regumate Equine is used to control oestrus ("heat") in mares. Once again, we have to ask "does my mare need Regumate", and if there is not a clear indication of continued low progesterone levels (generally 4 ng/ml is considered sufficient to maintain pregnancy, although 2 ng/ml is considered sufficient by some researchers 5 ), then the answer is probably "no". n Regu-Mate can help alleviate moodiness and temperament changes associated with estrus. The usual dose is 1 ml per 110 lbs body weight once daily for 15 consecutive days. Oral administration of altrenogest to mares at a dose of 0.044 mg/kg body weight for 15 days resulted in intervals to estrus and ovulation of 5.0 ± 2.4 days and 10.2 ± 3.6 days, respectively. The Dial-A-Dose system (2mL to 15mL) allows for an easy setting of dosage and accuracy of dosage. The Regumate needed to be given daily, as near exact the time as possible.never skip a dose. 2013). It's easy to administer &ndash orally or top-dressed on grain. REGU-MATE (altrenogest) Solution 0.22% is contraindicated for use in mares having a previous or current history of uterine inflammation (i.e., acute, subacute, or chronic endometritis). Any discharge from the vulva warrants a call to your veterinarian. Dosage and Administration: Hormone free and totally safe to handle. Careful inspection of the udder and external genitalia should occur at frequent intervals throughout gestation. This study provided the following data: Regu-Mate is a solution for oral use only and is available in a 1,000 ml bottle. Treated mares received 2 mL Regu-Mate ® (altrenogest) Solution 0.22% /110 lb body weight (2 × dosage recommended for estrus suppression) from day 20 to day 325 of gestation. Five mares served as infected, untreated control animals (Group UNTREAT). in mares that have previously lost their foal to placentitis, although there is not scientific data to support the protocol, is to give these mares, antibiotics and flunixin meglumine, for the first 10 days of the month beginning around the 7th month of gestation. It can be given directly by mouth or on your mare's grain ration. Progesterone and related natural hormones are released from the corpus luteum on the ovary and from certain structures of the placenta. . It can be given directly by mouth or on your mare's grain ration. It is supplied as a liquid to be given directly into the mouth, or added to a small amount of food. The regumate I am feeding is pig regumate which consists of a different proportion of altrenogest to horse regumate, and the dosage of pig regumate for a horse of Meg's size is 6mls, so I am feeding over double the recommended dose in order to keep the symptoms I have described above at bay. Regumate® Equine 2.2 mg/ml oral solution for horses. Regumate® Equine 2.2 mg/ml oral solution for horses. Many show mares are on it year round and at a higher dose than the recommended amount. Possible Side Effects When used as directed on the label, Regu-Mate is usually tolerated well by horses. ll natural product to help your mare get off hormones and shots. This study provided the following data: 1. The progestin is administered once daily for 10 to 14 days and a dose of prostaglandins is typically In daily stud practice mares are often supplemented with exogenous progestin (altrenogest, Regumate™) as a result of suspicions of inadequate progesterone production or a clinician's frustration when facing mares that repeatedly fail to conceive or carry a pregnancy to term (Canisso et al. Treated mares received 2 mL Regumate solution 0.22%/110 lb body weight (2x dosage recommended for estrus suppression) from day 20 to day 325 of gestation. Altrenogest is not detected in commercial progesterone assays. Regu-Mate Solution 0.22% produces a progestational effect in mares. 10 to 50 µg, IM, q 6 h to 12h. Beside this, how do you use mare Regumate? Administer orally with dose syringe or by placing directly on feed. The cost-effective alternative to Regu-Mate®. Active ingredient: Altrenogest. Nr. Cervical closure . 65% less cost than Regumate. It is meant to be used for the suppression of estrus in mares. Regu-Mate is for administration orally on back of mare's tongue or applied to usual grain ration. A dosage cap for adding Regumate to food is also provided, and if adding to food, the appropriate dose should then be poured into the measuring compartment. Regu-Mate is a solution for oral use only and is available in a 1,000 ml bottle. It is also commonly used to help maintain pregnancy in mares determined to be at risk of pregnancy loss. INDICATIONS: Regu-Mate ® (altrenogest) Solution 0.22% is indicated to suppress estrus in mares. The Regu-mate Dosing Device helps to make dosing easy. Effective only in mares during late transitional phase: Altrenogest (Regu-Mate) Intervet/Shering-Plough: 0.044 mg/kg/day orally for 10-15 days: Effective only in mares during late transitional phase. Introduction. donor mare with a specific recipient mare. Regumate Equine 2,2 mg/ml 1L. Species: Horses and other equidae. Many show mares are on it year round and at a higher dose than the recommended . Altrenogest is used for suppression of estrus. Studies have been conducted to support suppression of behavioural signs of oestrus in cycling mares for 7 days following administration of Altrenogest Injection. Treated mares received 2 mL Regumate porcs solution 0.22%/110 lb body weight (2x dosage recommended for estrus suppression) from day 20 to day 325 of gestation. Regumate® is a man made progestane, altrenogest, that has strong progesterone properties and can be placed in the feed. acute, subacute or chronic endometritis). a Grade II or greater uterine biopsy result), or current uterine inflammations (i.e. When you removed the Regumate the cycling, the moodiness, the soreness and the teasing of the stallions returned really fast. GnRH agonist; stimulation of follicular development in . Altrenogest is also used in the support of high-risk pregnancies at twice the normal dose or 0.088 mg/kg, which is approximately 2.0 mL per 110 lbs of body weight. Each ml of Regu-Mate Solution contains 2.2 mg altrenogest oral progestin. The recommended dosage of Regu-Mate is 1 ml per 110 lbs body weight given once daily for 15 consecutive days. This leads him to believe they aren't getting it just to manage the side effects of ovulation. Regu-Mate requires a prescription from your veterinarian. Regumate is a progesterone. Wedgewood Pharmacy's stringent quality control programs help ensure that our injection solutions meet the specifications and high standards of the pharmacy industry. Regumate is the trade name for a synthetic hormone called altrenogest. DOSAGE CHART: Approximate Weight In Pounds Dose in mL 770 7 880 8 990 9 1100 10 1210 11 1320 12. It makes measuring the dose as easy as turning a dial, and limits skin exposure to the drug. DA: 20 PA: 98 MOZ Rank: 92. Regu-Mate® (altrenogest) nih.gov Some mares seem to need to stay on it year 'round though, and they will obviously come in to season when it's stopped (which is why it's often used to cycle mares for breeding purposes) which . Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal. Trending A Blue Whale'S Tongue Weighs More Than An Elephant? Active Ingredients: Each ml of Regu-Mate (altrenogest) Solution 0.22% contains 2.2 mg of altrenogest in an oil solution. Regumate is probably the most broadly used drug in controlling mare habits. As you already know,giving Regumate daily is to provide a progesterone-type hormone to aid in maintaining the pregnancy through day 90-120. The dosage form available for Altrenogest is Injection Solution. Similarly, it may be necessary to alter or manipulate the estrous cycle of a mare for a scheduled breeding due to stallion availability. TOP TIP you can get regumate porcine which is essentially the same thing but designed for pigs - heaps cheaper - like £60 a bottle and works just as well. $ 140.00 $ 110.00. Altrenogest is contraindicated in mares having a previous or current history of uterine inflammation (ie, acute, subacute, or chronic endometritis). Horses: Regu-Mate ® Solution 0.22% is contraindicated in pregnant mares and in mares having a previous history of uterine inflammation (i.e. Para a sincronização do cio das marrãs, administrou-se: progestágeno altrenogest (Regumate®, MSD Saúde Animal) (20 mg) por 18 dias; gonadotrofina coriônica equina (eCG-Novormon®, Zoetis), 24 horas após a retirada do altrenogest na dose de 600 UI e 2,5 mg do hormônio liberador de Gonadotrofinas (GnRH - Sincrofort®, Ouro Fino), como . Management. The dose is 5-10 mg (1-2 cc/mare) IM. Meg is on it permanently. Natural or synthetic gestagen therapy may exacerbate existing low-grade or "smoldering" uterine inflammation into a fulminating uterine infection in some instances (package insert; Regu-Mate®). Side effects include transient sweating and colic. Each ml of Regumate Equine contains Altrenogest 2.20 mg as active sustance and Butylhydroxyanisole (E3210) 0.07mg, Butylhydroxytoluene (E321) 0.07mg, Sorbic acid (E200) 1.50mg and Benzyl alcohol 10.00mg as excipients. Ingredients Contains altrenogest 2.2 mg/mL in an oily solution. Administering prostaglandin on the last day of treatment may improve results if the mare(s) ovulated during treatment. Twelve mares (Group TREAT) were infected and given trimethoprim sulfamethoxazole (30 mg/kg, PO, q 12h), pentoxifylline (8.5 mg/kg, PO, q 12h) and altrenogest (0.088 mg/kg, PO, q 24h) from the onset of clinical signs to delivery of a live foal or abortion. These mares remain on progesterone or Regumate throughout their pregnancy. Buserelin *. Use to schedule estrus in mares and breeding in mares to maximize breeding efficiency. She is a different horse on it - tried all the herbal moody mare oestress type stuff and none of them helped but . 2 people found this helpful. Regu-Mate provides safe, effective suppression of estrus in mares - 95% effective after 3 days of treatment. It contains the active synthetic progestin - altrenogest. Not a subscriber? It can be given daily to a mare early in her season and usually within 3 days it will stop that oestrus. Regu-Mate Solution 0.22% is indicated to suppress estrus in mares. Product: Regumate® Equine 2.2 mg/ml oral solution for horses. When altrenogest is fed for 15 days, most mares express estrus within 3.5 to 5 days and ovulate 9 to 11 days after treatment. Facilitates scheduling of mares during the breeding season. This study provided the following data: Administer solution directly on the base of the mare's tongue or on the mare's usual grain ration. This study provided the following data: In filly offspring (all ages) of treated mares, clitoral size was increased. The same formulation and active ingredient a Regu-Mate®. Regu-Mate Dosing Device . Regumate fans often say it makes the mare feel "content" — their reasoning being that pregnant mares feel "content." Administer with a dose syringe or add to grain ratio Regumate Equine is a clear, light yellow oily solution. Administered orally as an oil solution, the labeled dose of altrenogest is 0.044 mg/kg (1 ml per 110 lb of body weight). Who is Regu-Mate Solution for? Altrenogest (Regu-Mate ®) (2.2 mg/ml) 0.088 mg/kg, orally, q 24h or 0.044 mg/kg, orally, q 12h (double dose) Maintenance of pregnancy in high risk mares. Hormones with progesterone-like activity are called progestanes. Regumate is the most widely used drug in controlling mare behavior. Altrenogest (Intervet, Millsboro, DE) is a synthetic progestin approved for use in horses for the purpose of suppressing estrus. Therapeutic indication: Pharmaceuticals: Hormones and therapeutically related products: Other sex hormones. Regu-Mate ® (altrenogest) Solution 0.22% is indicated to suppress estrus in mares. Regu-Mate requires a prescription from your veterinarian. Can use on mares and geldings to calm and relax. What's in it? Regu-Mate is for administration orally on back of mare's tongue or applied to usual grain ration. For owners or exhibitors of mares, you will be limited to the use of Regumate to control estrous. WHICH MARES WILL RESPON D TO REGU-MATE® (altrenogest) SOLUTION 0.22%: Extensive clinical trials have demonstrated that estrus will be suppressed in approximately 95% of the mares within three days; however, the post-treatment response depended on . n Regu-Mate lets you breed earlier in the season by helping transitional mares cycle . This facilitates the attainment of regular cyclicity during the transition from winter anestrus to the physiological breeding season. Strengths: 2 strengths of Altrenogest Injection Solution are available, ranging from 150 mg/ml to 225 mg/ml. Decisions of the FEI General Assembly pertaining to Veterinary matters Authorisation of treatment with altrenogestThe Assembly approved a proposed rule change enabling the treatment of mares with excessive oestrus behaviour with Regumate® (altrenogest), under the following conditions:1. only for mares,2. 17 By managing the reproductive cycle, horse owners have more control over . The only multi-herbal mare product you can show and race on. Progestin treatment. Regu-Mate altrenogest Solution 0.22% produces a progestational effect in mares. Available in 1000 mL bottles along with a dispensin cap. Regumate® is occasionally administered off-label to stallions in an attempt to suppress undesirable male behavioral characteristics Regu-Mate® is contraindicated for use in mares having a previous or current history of uterine inflammation. This allows a regular cycle during the transition from winter anestrus to the physiological breeding season in mares with active ovaries. Your records should clearly indicate which mares are . Regu-Mate Solution 0.22% produces a progestational effect in mares. At the beginning of week 9 (treatment period) mares were randomly divided into two groups with six mares treated daily with altrenogest (Regumate, Hoechst Roussel) at the recommended dose rate of 0.044 mg/kg body weight per os by syringe. ReguMare helps support the normal hormonal balance of your mare when temperament and marish behaviour adversely affects safe handling, willingness to work and performance. Regu-Mate® is commonly used in the equine industry to suppress estrus in performance mares and to synchronize estrous cycles for . Helps balance mood and focus for more consistent training and performance. Allows for predictable occurrence of estrus following withdrawal of the drug. This study provided the following data: 1. Active Ingredients: Each ml of Regu-Mate (altrenogest) Solution 0.22% contains 2.2 mg of altrenogest in an oil solution. Pregnant mares should gain weight moderately during pregnancy and have a natural glow to their coats. at the manufacturers recommended dosage and3. Regumate is a progesterone. All 4 mares got better within 24 hours - and continued to improve. Supports healthy hormone balance in mares for more consistent training and Further, it is considering also prohibiting the use of a stronger progestin, Altrenogest or Regumate, in all geldings and stallions. 1000ml What is Regu-Mate Solution? Like progesterone birth-control pills or implants, it suppresses estrus by tricking the brain into thinking the mare is pregnant. The mares I took care of were of top bloodlines and worth a fortune. Like progesterone birth-control tablets or implants, it suppresses estrus by tricking the mind into pondering the mare is pregnant. dose rates to sedentary mares had no effect on dominance .
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